Spanish Flu Pandemic of 1918

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The deadliest virus in modern history, perhaps of all time, was the 1918 Spanish Flu. It killed about 20 to 50 million people worldwide, perhaps more. The total death toll is unknown because medical records were not kept in many areas.

The pandemic hit during World War I and devastated military troops. In the United States, for instance, more servicemen were killed from the flu than from the war itself. The Spanish flu was fatal to a higher proportion of young adults than most flu viruses.

The pandemic started mildly, in the spring of 1918, but was followed by a much more severe wave in the fall of 1918. The war likely contributed to the devastating mortality numbers, as large outbreaks occurred in military forces living in close quarters. Poor nutrition and the unsanitary conditions of war camps had an effect.

A third wave occurred in the winter and spring of 1919, and a fourth, smaller wave occurred in a few areas in spring 1920. Initial symptoms of the flu were typical: sore throat, headache, and fever. The flu often progressed rapidly to cause severe pneumonia and sometimes hemorrhage in the lungs and mucus membranes. A characteristic feature of severe cases of the Spanish Flu was heliotrope cyanosis, where the patient’s face turned blue from lack of oxygen in the cells. Death usually followed within hours or days.

Modern medicine such as vaccines, antivirals, and antibiotics for secondary infections was not available at that time, so medical personnel couldn’t do much more than try to relieve symptoms.

The flu ended when it had infected enough people that those who were susceptible had either died or developed immunity.