Although, though, even though, in spite of, despite

Although, though, even though, in spite of, and despite being all words used to express contrast or opposition between two ideas. They are often used to show that one idea is unexpected or surprising given the other.

1. Although and Though: Although and though are conjunctions that are used to introduce a clause that contrasts with a previous statement. They are often used interchangeably, but "although" is considered more formal. Examples:

- Although I studied for hours, I still failed the exam. 

- Though he is very wealthy, he leads a simple life.

2. Even Though: Even though is similar to although and though, but it adds emphasis to the contrast being made. Examples:

- Even though it was raining, he still went for a run.

- She decided to take the job, even though it meant moving to a new city.

3. In Spite of and Despite: In spite of and despite are prepositions used to indicate that one thing happens or is true despite another. They are followed by a noun or a gerund. Examples:

- In spite of the rain, they had a great time at the concert.

- Despite the fact that she was tired, she stayed up late to finish her project.

Note: "Despite of" is incorrect usage, "despite" should be used alone without "of".

In summary, although, though, even though, in spite of, and despite are all useful words for expressing contrast and opposition in a sentence. They can be used interchangeably in some cases, but it's important to pay attention to the nuances of meaning and formality.